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Clinical Trials

All Clinical Trial Listings

Please click the links below to go to each Clinical Trial Listing on this page:

Pilot   -   Phase 1   -   Phase 1 & 2   -   Phase 2   -   Natural History   -   Screening   -   Other

All Clinical Trials Information

Protocol Number Title Study Status PI Website Section
Pilot
07C0086 Pilot Study of Educational Interventions in Pediatric Hematopoietic Stem Cell Donors to Increase Knowledge of Donation and Transplantation Procedures Currently Accruing Wiener, Lori
Link Psychosocial
Hematopoietic Stem Cell Transplantation
GVHD
07C0206 A Pilot Study of Tumor Vaccination and RHIL-7 Following Standard Multimodality Therapy in Patients with High Risk Pediatric Solid Tumors Currently Accruing Mackall, Crystal
Link Solid Tumors
11C0113 A Pilot Study of Genetically Engineered NY-ESO-1 Specific (c259) T cells in HLA-A2+ Patients with Synovial Sarcoma Currently Accruing Mackall, Crystal
Link Solid Tumors
Phase 1
10C0219 A Phase I Trial of Lenalidomide and Radiotherapy in Children with Diffuse Intrinsic Pontine Gliomas and High-grade Gliomas Currently Accruing Warren, Kathy
Link Neuro-Oncology
11C0073 A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation from Related or Matched Unrelated Donors in Pediatric Patients with Solid Tumors and Leukemias Currently Accruing Shah, Nirali
Link Hematopoietic Stem Cell Transplantation
Solid Tumors
Hematologic Diseases
11C0161 A Phase 1 Study of the Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor AZD6244 Hydrogen Sulfate (Selumetinib Sulfate) in Children with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN) Currently Accruing Widemann, Brigitte
Link Pharmacology and Experimental Therapeutics
Neurofibromatosis
11C0191 Phase 1 and Pharmacokinetic Study of AZD6244 for Recurrent or Refractory Pediatric Low Grade Glioma Currently Accruing Warren, Kathy
Link Neuro-Oncology
12C0112 Phase I Study of T Cells Expressing an Anti-CD19 Chimeric Receptor in Children and Young Adults with B Cell Malignancies Currently Accruing Lee, Daniel
Link Hematologic Diseases
13C0042 ADVL1211: A Phase I Study of XL184 (Cabozantinib, IND# 116059) in Children and Adolescents with Recurrent or Refractory Solid Tumors, Including CNS Tumors Currently Accruing Widemann, Brigitte
Link Solid Tumors
Pharmacology and Experimental Therapeutics
Neuro-Oncology
13C0064 An Open-Label, Multicenter, Single-Arm, Phase I Dose-Escalation with Efficacy Tail Extension Study of RO5185426 in Pediatric Patients with Surgically Incurable and Unresectable Stage IIIC or Stage IV Melanoma Harboring BRAFV600 Mutations Currently Accruing Merchant, Melinda
Link Solid Tumors
14C0059 A Phase I Trial of T Cells Expressing an anti-GD2 Chimeric Antigen Receptor in Children and Young Adults with Non-neuroblastoma, GD2+ Solid Tumors Currently Accruing Mackall, Crystal
Link Solid Tumors
14C0024 Defibrotide for Patients with Hepatic Veno-Occlusive Disease (VOD): A Treatment IND Study Currently Accruing Shah, Nirali
Link
13C0152 A Phase I Study of Autologous Activated Natural Killer (NK) Cells +/- rhIL15 in Children and Young Adults with Refractory Solid Tumors Currently Accruing Merchant, Melinda
Link Solid Tumors
14C0129 SARC025: Phase 1 Study of a Combination of the PARP Inhibitor, Niraparib and Temozolomide in Patients with Previously Treated, Incurable Ewing Sarcoma Currently Accruing Helman, Lee
Link Solid Tumors
Phase 1 & 2
12C0135 Phase I/II Trial of Mithramycin in Children and Adults with Refractory Extracranial Solid Tumors (Phase I) or Ewing Sarcoma and EWS-FLI1 Fusion Transcript (Phase II) Currently Accruing Widemann, Brigitte
Link Solid Tumors
Pharmacology and Experimental Therapeutics
12C0213 PBTC-033 A Phase I/II Study of ABT-888, an Oral Poly (ADP-ribose) Polymerase Inhibitor, and Concurrent Radiation Therapy, Followed by ABT-888 and Temozolomide, in Children with Newly Diagnosed Diffuse Pontine Glioma (DIPG) Currently Accruing Warren, Kathy
Link Neuro-Oncology
14C0013 A Phase I/II Trial of Ganetespib in Combination with the mTOR Inhibitor Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors Currently Accruing Widemann, Brigitte
Link Pharmacology and Experimental Therapeutics
Phase 2
08C0130 A Phase II Trial of Peginterferon alfa-2b (Pegintron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform Neurofibromas  Currently Accruing Widemann, Brigitte
Link Neurofibromatosis
09C0104 A Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional, Phase II.5 Study of AZD0530, a Selective Src Kinase Inhibitor, In Patients with Recurrent Osteosarcoma Localized to the Lung Currently Accruing Merchant, Melinda
Link Sarcomas
12C0058 A Phase II Study of Everolimus (RAD001) for Children with Neurofibromatosis Type-1 and Chemotherapy-Refractory Radiographic Progressive Low-Grade Gliomas Currently Accruing Warren, Kathy
Link Neuro-Oncology
Neurofibromatosis
12C0148 SARC016: Phase II Study of the mTOR Inhibitor Everolimus in Combination With Bevacizumab in Patients With Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors Currently Accruing Widemann, Brigitte
Link Pharmacology and Experimental Therapeutics
Neurofibromatosis
12C0136 A Phase II Randomized Trial of Lenalidomide in Pediatric Patients With Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas Currently Accruing Warren, Kathy
Link Neuro-Oncology
13C0208 Phase II Trial of Vandetanib (ZD6474, Caprelsa(R)) in Children and Adults with Wild-Type Gastrointestinal Stromal Tumors Currently Accruing Arnaldez, Fernanda
Link Pharmacology and Experimental Therapeutics
13C0191 A Molecular Biology and Phase II Study of Imetelstat (GRN163L) in Children with Recurrent High-Grade Glioma, Ependymoma and Diffuse Intrinsic Pontine Glioma Currently Accruing Warren, Kathy
Link Neuro-Oncology
14C0116 A Randomized Controlled Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated with Cranial Radiation for Brain Tumors Currently Accruing Wolters, Pamela
Link Psychosocial
Neuro-Oncology
Natural History
04C0275 Targeted Oncolytic Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's Disease with Laboratory and Clinical Correlates of Disease Activity  Currently Accruing Yarchoan, Robert
Link
08C0079 Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromatosis Type 1 Currently Accruing Widemann, Brigitte
Link Neurofibromatosis
04C0281 Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease Currently Accruing Pavletic, Stephen
Link GVHD
12C0178 Longitudinal Assessment and Natural History Study of Children and Young Adults With Medullary Thyroid Carcinoma Currently Accruing Widemann, Brigitte
Link Medullary Thyroid Carcinoma
Pharmacology and Experimental Therapeutics
14C0113 Effects of an Internet Support Group for Parents of a Child with Neurofibromatosis Type 1 Currently Accruing Peron, Staci
Link Psychosocial
Neurofibromatosis
Screening
01C0157 Eligibility Screening and Tissue Procurement for the National Cancer Institute (NCI), Pediatric Oncology Branch (POB) Clinical Research Protocols Currently Accruing Mackall, Crystal
Link
Other
01C0030 Short-Course EPOCH - Rituximab in Untreated CD-20+ HIV-Associated Lymphomas  Currently Accruing Wilson, Wyndham
Link Hematologic Diseases
02C0313 Cancer Risk in Xeroderma Pigmentosum Heterozygotes Currently Accruing Kraemer, Kenneth
Link
03C0278 A Comparative Study of Pediatric CNS Tumor Activity as Assessed by 18F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI) Currently Accruing Warren, Kathy
Link Neuro-Oncology
04C0102 Hematologic Malignancy Biology Study Currently Accruing Fry, Terry
Link Hematologic Diseases
06C0219 An Exploratory Study of Biologic and Pathophysiologic Effects of Radiation Therapy in Pediatric Patients with Central Nervous System Tumors Currently Accruing Warren, Kathy
Link Neuro-Oncology
07C0110 Analysis of Stored Data Collected from Individuals Administered Neurobehavioral Assessments on IRB-approved Protocols Currently Accruing Wolters, Pamela
Link Psychosocial
Hematologic Diseases
Gastrointestinal Stromal Tumor
Hematopoietic Stem Cell Transplantation
Medullary Thyroid Carcinoma
Neuro-Oncology
Neurofibromatosis
Solid Tumors
98C0037 Treatment of Children with Cancer Currently Accruing Mackall, Crystal
Link
10C0086 Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies Currently Accruing Javed, Khan
Link Solid Tumors
10C0111 Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research-Network (CCRN) Children's Oncology Group Currently Accruing Mackall, Crystal
Link
09M0022 The Use of a Distress Thermometer in a Pediatric Research Setting: An Exploratory Currently Accruing Pao, Maryland
Wiener, Lori
Link Psychosocial
09M0194 Characterizing Lone Parenting: A Multi-Institutional Pilot Study of the Perceptions of Support and Perceived Stress of Lone Parents of Children with Cancer Currently Accruing Pao, Maryland
Wiener, Lori
Link Psychosocial
OHSR5018 The Roles and Training Needs of Pediatric Psycho-Oncology Providers Currently Accruing Wiener, Lori
  Psychosocial
OHSR4800 ShopTalk: An Examination of the Utility and Feasibility of a Therapeutic Board Game Currently Accruing Wiener, Lori
  Psychosocial
OHSR4799 Psychosocial and Education Intervention for Pediatric Patients on Medical Isolation Currently Accruing Wiener, Lori
  Psychosocial
12C0160 Validation of the English Version of the Pain Interference Index and the Pain Rating Scale in Children, Adolescents, and Young Adults With Chronic Illness and Their Parents Currently Accruing Peron, Staci
Link Psychosocial
Neurofibromatosis
Solid Tumors
Hematologic Diseases
12C0206 Understanding the Perceived Influence of Childhood Cancer on the Parents' Marital/partner Relationship: A Descriptive Study Currently Accruing Wiener, Lori
Link Psychosocial
14C0079 An Exploratory Study of Voicing My CHOiCES as a Tool for Advanced Care Planning in Young Adults with Metastatic, Recurrent, or Progressive Cancer Currently Accruing Wiener, Lori
Link Hematologic Diseases
Medullary Thyroid Carcinoma
Neuro-Oncology
Neurofibromatosis
Solid Tumors
Psychosocial
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